Lee J, Boescke R, Tang PC, Hartman BH, Heller S, Koehler KR†*. Hair follicle development in mouse pluripotent stem cell-derived skin organoids. Cell Reports 22, 242-254 (†Lead Contact, *Corresponding Author, Highlighted in Nature and on NPR's Science Friday


Koehler KR†*, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E*. Generation of inner ear organoids with functional hair cells from human pluripotent stem cells. Nature Biotechnology 480, 547. http://doi.org/10.1038/nbt.3840 (†Lead Contact, *Corresponding Author, Cover Image, Highlighted in NBT News and Views and Cell Stem Cell Previews)

Nie J, Koehler KR, Hashino E. Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture. Methods in Molecular Biology 1597, 67-83. 


DeJonge RE, Liu XP, Deig CR, Heller S, Koehler KR*, Hashino E*. Modulation of Wnt signaling enhances inner ear organoid development in 3D culture. PloS One, 11(9), e0162508. http://doi.org/10.1371/journal.pone.0162508 (*Corresponding Author)

Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. Nature Communications, 7, 11508. http://doi.org/10.1038/ncomms11508


Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E. Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. PloS One 10(8):e0135060.


Koehler KR*, Hashino E*.  3D mouse embryonic stem cell culture for generating inner ear organoids. Nature Protocols 9(6):1229–1244 (*Corresponding Author; Cover Image)


Koehler KR*, Mikosz AM, Molosh AI, Patel D, Hashino E*. Generation of inner ear sensory epithelia in a defined 3D culture. Nature 500(7461):217-221 (*Corresponding Author; Highlighted in Cell, BioTechniques, 8-Star F1000 recommendation, and Nature Neuroscience’s NeuroPod)


Koehler KR, Tropel P, Theile JW, Kondo T, Cummins TR, Viville S, Hashino E. Extended passaging increases the efficiency of neural differentiation of induced pluripotent stem cells. BMC Neuroscience 12(1):82-95